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Preclinical studies have examined how oxytocin receptor activation influences the hypothalamic-pituitary-adrenal axis, cortisol responses to social stressors, and amygdala reactivity in animal models

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Several SCFAs, especially butyrate, are moderately potent HDAC inhibitors

2 Animal models for CIPN studies Animal models are frequently used to study the pathogenesis of CIPN and more importantly, to evaluate the drug efficacy in preventing or reversing CIPN symptoms (Hoke and Ray, 2014)